A Tool on Pharmaceutical Cocrystal to Enhance the Drug Properties Those Comes Under BCS Class II and IV
Balu S. Khandare
Sch Acad J Pharm | 443-452
DOI : 10.36347/SAJP.2019.v08i09.001
In pharmaceutical field various types of dosage forms are present and discovered continuously but some dosage form
are have some solubility, stability or any other issues as per BCS classification system so these problem are overcome
by using the formation of some solid dosage form like pharmaceutical cocrystals. During formation of pharmaceutical
cocrystal molecules structure are important like hydrogen bonding, Crystal Engineering, Van der Waal‟s Interactions,
Interaction involving π-system, Van der Waal‟s Interactions, and Supramolecular synthon etc. In supramolecular
synthons certain types of bonding between the functional group like acid-acid, acid-pyridine, pyridine- pyridine etc.
Formations of cocrystal are different techniques based on requirement of study. Basically use solvent evaporation,
solvent assisted grinding, hot melt extrusion, slurry method, anti-solvent, cooling method etc. use to form
pharmaceutical cocrystals. In pharmaceutical cocrystal contain API and Cocrystal coformer are present and theses
final cocrystal characterized by the different techniques like SCXRD, PXRD, DCS,FTIR and NMR. Cocrystal is
basically important to improve the solubility, bioavailability, stability, and dissolution rate of pharmaceutical dosage
Meditation: And the Human Mind
Saptarshi Panigrahi, Riyanka Sengupta, Pallab Das
Sch Acad J Pharm | 453-455
DOI : 10.36347/SAJP.2019.v07i09.002
Meditation is a practice where an individual uses a technique – such as mindfulness, or focusing their mind on a
particular object, thought or activity – to train attention and awareness, and achieve a mentally clear and emotionally
calm and stable state. Meditation, according to the spiritual meaning of the term, is not a process of the mind, but of
the spirit. It goes through two stages: the preliminary one which can be defined as concentration, and the final one
which can be called contemplation. Contemplation consists of gathering our attention with devotion in God, and
raising it to one's own focal Center in the body. Mystics, Saints and Masters call this Center with different names.
Christ calls it the single eye (aplus in the Greek text, Mathew 6:22) and St. Agustin calls it the "eye of the soul"
(Confessions 7:10), while in the East it is called the third eye, or "tenth door" in order to distinguish it from the nine
openings of the body (eyes, ears, nostrils, mouth and the two lower openings) tied to the plane of the senses. With the
awakening of the "eye of the soul" or inner eye, the human soul may contemplate the Light of God, an experience
which is common to the major mystics and Saints, both Christians and non-Christians of the East and the Middle East.
Thus, all the Scriptures affirm that God is Light. Saint Agustin and many other Saints actually speak about the
manifestation of God as Light. The human soul also has an inner ear with which it can tune into the Divine Power or
Word vibrating in the entire creation, the sacred creative Sound. The Divine manifestation (or Holy Ghost), in the two
forms of Celestial Lightand Sound, was experienced by the Apostles at Pentecost (Acts 2:2-4).
Original Research Article
Sept. 30, 2019
Therapeutic Potentials of Bioactive Compounds in Some Species (Amberboa Tubiflore, Anacyclus Clavatus and Anvillea Garcinii) in the Family Asteraceae
Seham TM Oshkondali, Manal M Elshili, Nadea Almunir, Ahlam Rashed, Nouri Kushlaf, A.M.EL-mahmoudy, Ameerah Shaeroun, Hamed Alqamoudy, Ahmed Belgasem Ahmed, Khalifa.S.Mohamed
Sch Acad J Pharm | 456-460
DOI : 10.36347/SAJP.2019.v07i09.003
The plants worldwide used as a traditional medicine for treating of several disorders. Many biological activities have
been achieved by a large number of secondary metabolites which extracted from these medicinal plants. The bioactive
compounds presented in a different concentration in this plant family according to the reagent used for extraction. In
this study we concentrate on three species from the family Asteracea which collected from a specific area in Libya.
The active compounds have been isolated by using different types of reagent. Also in this research, we have
summarized the pharmaceutical prospecting of natural compounds such flavonoids, sesquiterpenes, fatty acids,
lignans, sterols and other metabolites isolated from the genus Amberboa, Anacyclus and Anvillea and their progresses
in biotechnological applications as pharmaceuticals for the three species.