Original Research Article
July 29, 2020
Correlation of Vascular Adhesion Molecule in Subjects without Vascular Complication
Geetha Bhaktha, Manjula B, Rangantha M, Gurupadappa K, Parameshwara S
SAS J Med | 161-165
DOI : 10.36347/sasjm.2020.v06i07.001
An established independent risk factor for Cardio Vascular Disease (CVD) is diabetes. .Cardiovascular (CV) morbidity is a main burden in patients with type 2 diabetes mellitus (type 2 DM), with endothelial dysfunction as an early indicator of diabetic vascular disease that is linked to the presence of a low-grade vascular inflammation. Since CAM is an index of inflammatory endothelial activation, a assessor of conventional cardiovascular risk factor evaluating it in an early stage would reduce the burden of morbidity and mortality among the DM subjects. Materials and Methods: This is a cross sectional study where in 36 patients with no vascular complication, matched with 33 controls were selected from OPD of Department of General Medicine. The cases where diabetic for at least 1 year. VCAM-1 levels were estimated by commercial kit available from Ray Biotech Pvt. Ltd by ELISA method. Result: Diabetic subjects showed a higher levels of VCAM-1 than the Normal subjects. When correlation beween the two groups were analysed, VCAM-1 showed significant correlation with the duration of diabetes (p=.002, r=.494). When genderwise correlation was ploted, it was seen that in diabetic female subjects the difference was significant (p=.007, r=.523) with respect to VCAM-1 molecule. Conclusion: Though the clinical manifestation of vascular complication is not identifiable, the simulation for the expression of VCAM-1 molecule is evident. Hence VCAM-1 may be used as an early marker for vascular complications.