DOI: 10.36347/sjams.2019.v07i11.030

Pages: 3641-3644

Antimicrobial resistance has emerged as a challenging threat in the healthcare sector with the micro organisms developing newer mechanisms for resistance against the first line and also the newer antibiotics available. The number of infections particularly caused by the gram negative bacteria have been ever increasing. It is known that most of the clinically relevant bacteria are capable of acquiring and expressing resistance to antimicrobial agents commonly used to treat infections. Clinicians generally use the Carbapenem antibiotics as a last resort in patients who do not respond to the beta lactams, including the extended spectrum penicillins and the cepahalosporins. The present study was undertaken, to determine the prevalence and bacteriological profile of Carbapenem resistant Gram negative bacteria in the clinical isolates of admitted patients at a tertiary care hospital Navi Mumbai. This was a prospective observational study conducted at Dr D Y Patil Hospital Nerul Navi Mumbai, from January 2019-June2019. The clinical specimens received in the microbiology laboratory were processed as per the standard microbiological methods. The bacteria were identified using manual culture techniques and were tested for antibiotic susceptibility by the Kirby Bauer Disc Diffusion method as per the CLSI guidelines 2019. A total of 4040 samples were received in the microbiology laboratory from the in patient department. Out of which 1560 samples showed growth and 1114 samples were gram negative bacteria. Most commonly isolated organism was Klebsiella pneumonia (n=147, 56%) followed by Escherichia coli (n=74, 28%). Overall the most frequent source of bacterial isolation was Urinary tract infection (36%). Out of these 29% were Carbapenem Resistant. This concludes, a prevalence of 29% is considerably high and alarming. We have to restrict use of Carbapenems to prevent further increase in the resistance pattern. Early detection, isolation and contact precaution plays an important