Background: A virus which primarily causes inflammation of he liver. The hepatitis B virus can be transmitted in several ways including blood transfusion, needle sticks, body piercing and tattooing using unsterile instruments, dialysis, sexual and evenless intimate close contact, and childbirth. Acute on chronic liver failure (ACLF) is an acute hepatic insult manifested as Jaundice and Coagulopathy, complicated within 4 weeks by clinical ascites and/or Encephalopathy in a patient with previously diagnosed or undiagnosed Chronic Liver Disease/Cirrhosis. It is associated with high 28-day mortality rate ranging from 30% to 70%. Reactivation of Hepatitis B virus infection and super infection with hepatitis A or E are the major causes of ACLF in the Asian region. Liver transplantation is the only definitive therapy though it is not available everywhere and not feasible always. Again MARS therapy (Molecular Adsorbent Recirculating System) didn’t reduce mortality significantly. So, antiviral therapy should be started as soon as possible in patients with ACLF due to Hepatitis B irrespective of DNA and ALT status to improve hepatic dysfunction and rescue the patients from mortality. Aims: This randomized clinical trial was carried out with an aimto see survival among patients with acute on chronic hepatitis B liver failure 03 months after the antiviral (Tenofovir or Entecavir) therapy. Methodology: In this study a total of 32 acute on chronic Hepatitis B liver failure patients (age > 18 years with both sexes but male predominant) were included in Hepatology department of Bangabandhu Sheikh Mujib Medical University, Dhaka during January 2013 to December 2015. The patients were randomized into two groups: Tenofovir group (N=16) and Entecavir group (N=16) and followed at least for 03 months. Result: The total study population was 32 Tenofovir and Entecavir ware 15, 13(86.66) tenofovir and entecavir of 7 days. 6(60.00) tenofovir and entecavir of 8-15 days. 1(14.28) tenofovir....

Background: Post-operative blood loss remains a major problem after cardiopulmonary bypass. A common complication after Coronary Artery Bypass Grafting (CABG) is postoperative bleeding, which is considered as an important problem. Objective: The aim of this study is to study only patients who have never used drugs above so that it can assess postoperative bleeding in CABG with the absence of high-risk medications related to postoperative bleeding. Methods: This cross sectional study was carried out at the Department Of Cardiac Surgery in Bangabandu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2019 to December 2019. 50 patients who were candidates for CABG surgery participated in the study. Inclusions criteria included who were candidates for CABG surgery, avoiding the use of blood clotting drugs before surgery, avoiding the use of immunosuppressant, and the absence of an underlying medical condition such as kidney diseases. Patients with inflammatory, platelet diseases, or any coagulation disorder were excluded. All patients initially tested for hemoglobin, platelets and hemoglobin and International Normalized Ratio (INR). In addition to testing for hemoglobin, the amount of bleeding and packed red cell; frozen plasma and platelets were recorded. Results: Fifty patients who were candidates for elective surgery, including 33 men (66%) and 17 women (34%) were enrolled in this study. The mean patient age was 8.70+57.9years old. Test showed that mean hemoglobin level of patients before surgery was pre-operative of 1.5+12.4 g/dL, mean platelet was equal to 54.14+250.8 thousand/ μL and an average international normalized ratio (INR) was equal to 0.12+1.07. The results after surgery also showed that: The total units of given packed red cell; frozen plasma and platelets were (3.14+1.90; 2.34+2.36 and 0.06 +0.42). Also, postoperative hemoglobin was 1.30+10.30 g/dL, which significantly decreased compared to pre-operative hemoglobin. Bleeding in.....

Introduction: Febrile seizures are one of the common neurological problems encountered in pediatric practice and common cause of convulsions in young infants. Seizure was diagnosed by sudden alteration of behavior with abnormal movement of limbs, trunk, and face that might be associated with abnormal or fixed eye gaze with or without incontinence of urine or stool. In USA, South America and Western Europe between 2% and 5% of all children experience febrile seizure before 5 years. Aim of the study: To evaluate the clinical profile and investigations of febrile seizure in children. Material & Methods: This cross sectional study was conducted in Uttara Adhunic medical college hospital, Uttara, Dhaka, Bangladesh. The study was done in 6 months’ duration (1st November 2010 to 3oth April 2011), on the children of febrile seizure. Hundred (100) patients fulfilling inclusion and exclusion criteria were selected for this study. Data recorded in questionnaires forms into computer and analyzed by using SPSS-15.0 statistical software employing appropriate statistical test and determination of p value. This study was approved by Ethical Committee of the BCPS. Moreover, this study was done following the guideline of BMRC (Bangladesh Medical Research Council). Results: In this study, age distribution of the patients (n=100) were divided into three age groups. Incidence was most common in 1-2 years’ age group (43%), slightly lower in 5 months –1-year group (39%) and incidence declined sharply in 2-6 years’ age group which was 18%. Male to female ratio was 1.27:1. Ninety-two (92%) febrile seizures were of less than 15 minutes’ duration, 95% generalized, and single attack of seizure in 89% cases, incidence of 2 attack in 7% and more than 2 in 4% cases. Conclusion: Family history was positives in significant number of cases. No significant association found between this disease and any antenatal, natal, post-natal or childhood adverse events.