The contagious disease COVID-19 is a recently out-broken pandemic situation which threatens human kind all over the world. While considering the mortality and severity of this disease, the author attempted to identify the possible inhibition of RNA-dependent RNA polymerase (RdRP) or RNA replicase which catalyzes the replication of RNA from an RNA template by certain bioactive components. So certain herbs which are used as febrifuges in Siddha medicine were analyzed through molecular docking studies. The compounds Betulinicacid, Amaranthin, Betacyanin, Cadambine, 14 –deoxy Androgapholide, lupeol, Neoandrographolide, Tubulosin and Isovitexin have binding energy comparable to Remdesivir.

The intent of human being in the process of modernisation and becoming supernatural power to conquer the world lead to disaster to the mankind. In the process failed to realise the facts of infections which can be pandemic and take the lives of kith and kin even in the yester years and now also in the 21st century. The most fatal pandemic recorded in human history was the Black Death (also known as The Plague), which killed an estimated 75–200 million people in the 14th century [2-7]. Other notable pandemics include the 1918 influenza pandemic (Spanish flu) and the 2009 influenza pandemic (H1N1) [8-10]. The 18th, 19th, 20th and 21st century were noticed with number of diseases transmitted with bacteria and viruses. These diseases were transmitted on pandemicity and caused calamities, the socioeconomic status shattered. Current pandemics include HIV/AIDS and the 2019-20 Coronavirus. “An emerging infectious disease (EID) is one that has appeared and affected a population for the first time, or has existed previously but is rapidly increasing, either in terms of the number of new cases within a population, or its spread to new geographical areas” (e.g. SARS) [41]. There is no clear evidence on whether and how prior exposure to a strain of CoV can produce permanent immunity against the strain species or even cross-immunity for other CoV species [47]. At present 1.28% of GDP, India’s expenditure on health is still low although higher than before!!! Developed nations—the US (16.9%), Germany (11.2%), France (11.2%) and Japan (10.9%)—spend even more. India spends the least among BRICS countries: Brazil spends the most (9.2%), followed by South Africa (8.1%), Russia (5.3%), China (5%).

Background: Metabolic syndrome is a multiplex risk factor that arises from hyperglycemia /insulin resistance accompanied with abnormal fat function &central obesity& possibility to develop diabetes mellitus type-2, atherosclerosis & various diseases. Aim of study: To determine the effect of ropinirole & metformin on glycemic Parameters, insulin sensitivity and lipid profile associated with metabolic syndrome. Patients and methods: The present study was performed in diabetic and endocrine center from May 2016 to march 2018. Ninety female patients with metabolic syndrome participate in this study .They were allocated to three groups (each group contain 30 patients) first group put on diet restriction physical exercise only. Second group received metformin 750mg extended release orally once daily at night with diet restriction & physical exercise. Third group received ropinirole 0.25 mg orally after meal in morning with diet restriction & physical exercise. The duration of the study extended to 12 weeks. Blood samples were taken from each patient at zero time to determine base line level & after 12 weeks of treatment. The measured parameters were WBC, BMI, FBS, FI, HOMA-IR, Hb A1c, TC, TG, HDL, LDL. Results: Showed highly significant lowering effect of both ropinirole & metformin on the levels of the all parameters except HDL with high significant elevation, at the mean time all the parameters of the control were significantly changed. Conclusion: Both drugs improve glycemic parameters, insulin sensitivity and lipid profile in metabolic syndrome but metformin is slightly more powerful on these parameters.