DOI: 10.36347/sjams.2019.v07i11.036

Pages: 3668-3673

Background: Tuberculosis has emerged as a worldwide health concern with one-third of the world's population being affected by it. The arrival of novel anti-tuberculosis drugs has made it manageable. A number of investigations have been conducted on the issue regarding drug-induced hepatotoxicity; a number of which also include the anti-tubercular drugs, with extensive focus on Pyrazinamide followed by Isoniazid and Rifampicin respectively. None of the studies in this area fully collude with each other, thus, rigorous investigation of both the mechanism of development and risk factors associated with anti-tubercular drug-induced hepatotoxicity need to be conducted. This will help us in gradually getting rid of this deadly disease. Objectives: To determine the elements that makes a person on anti-tuberculosis treatment more susceptible to develop hepatic toxicity than the others. Analyze the biochemical alterations in such patients. To deduce any correlation and compare the age, sex, history of alcoholism, smoking, nutritional status in patients who develop hepatotoxicity. Materials and Methods: This study was conducted to determine the prevalence of hepatotoxicity in patients on the Cat-I RNTCP regimen in the O.P.D. of the Chest and Tuberculosis Department and RNTCP Centre of Dr. B.R. Ambedkar Memorial Hospital, Raipur, Chhattisgarh. It was a prospective, observational type of study with the aim to deduce the risk factors and biochemical alterations associated with the development of hepatotoxicity. Results: 4.6% of the patients developed hepatotoxicity during the period of study. Male sex, age greater than 35, malnourishment, poor socioeconomic status and chronic tobacco use were found to be the risk factors associated with the generation of hepatic toxicity. Conclusion: According to this study, age> 35 years, male sex, chronic tobacco use, malnutrition, and low socioeconomic status are the potential risk factors for the development of hepatotoxicity in patients on