DOI: 10.36347/sjams.2019.v07i11.051

Pages: 3732-3736

Multidrug-resistance is a major problem in the treatment of enteric fever caused by Salmonella enterica serovar Typhi/Paratyphi and is prevalent in parts of Asia and Africa. Reduced susceptibility/resistance to fluoroquinolones is highly prevalent, and sporadic cases of resistance to third-generation cephalosporins has also been reported in literature. The present study was undertaken to evaluate the magnitude of fllouroquinolone resistance and emergence of Ceftriaxone resistance among Salmonella enterica serovar Typhi/ Paratyphi A isolates, from a tertiary care hospital of North India. A total of 537 S. enterica isolates were obtained; 359 isolates (66.8%) were identified as Salmonella enterica serovar Typhi and 178 (33.2%) were identified as Salmonella enterica serovar Paratyphi A. Apprximately, 59% and 100% of the S. Typhi and S. Paratyphi A isolates, respectively were resistant to ciprofloxacin. Interpretation and conclusions: The incidence of S. enterica serovar Typhi and S. enterica serovar Paratyphi A isolates with resistance or decreased flouroquinolone susceptibility is very high. 1.7% of S typhi and 1.1% of S paratyhi A isolates were found resistant to ceftriaxone with an MIC of ≥64 µg/ml. The emergence of ceftriaxone resistant S. enterica strains needs prompt action in terms of control of the disease and further spread of the resistant strains.