DOI: 10.36347/sjams.2019.v07i11.066

Pages: 3804-3809

Introduction: Dengue infection is an arthropod borne disease caused by Dengue virus in humans. Dengue virus infection has more potential to produce severe form of the disease with more severe symptoms. Proper diagnosis of dengue fever is very important for its safe management. NS1 antigen test (nonstructural protein 1), is a test for dengue, introduced in 2006. It allows rapid detection on the first day of fever, before antibodies appear some 5 or more days later. Aim of the study: The aim of this study was to determine the pattern of hematological abnormalities in patients with NS1 positive dengue fever. Methods: It was a cross sectional study which was conducted among 300 patients tested for dengue admitted in the Department of Medicine, Sheikh Sayera Khatun Medical College, Gopalgonj from January 2017 to December 2017 with symptoms related to dengue fever. This study was approved by the ethical committee of the respective hospital previously. Proper written consents were obtained from all the patients with NS1 positive dengue fever before starting the intervention. Result: In our study it was found that, 90.8 % patients had primary dengue infection and 35.5% patients had secondary dengue infection. Most patients were between the ages of 10-20 years (26%), among them 19.7% were having primary dengue infection. Among 10-20 years of age 50% female patients were with false dengue. Among total NS1 positive patients platelet count was <150 x109/L in 30.43% (n=49) and <100 x109/L in 49.69% (n=80) patients. Out of total 161 participants 22.98% had thrombocytopenia Grade 1 which was the highest portion. Then 14.29% had Grade 2, 7.45% had Grade 3 and 3.73% had Grade 4 thrombocytopenia. Neutropenia (<2 x 109/L) was observed on 23 patients who had neutropenia in febrile phase and 43 had in critical phase. The mean value of neutrophil in febrile phase was 2.54 and in critical phase it was 1.76 which was statistically highly significant. Lymphocytopenia (<1x 109/L) was widely