DOI: 10.36347/sjams.2019.v07i04.001

Pages: 1355-1361

Introduction: The growth and development of fetus during pregnancy depends upon placenta as it is responsible for continuation and progression of a pregnancy in addition to fetal nutrition Study was carried out to investigate the morphological changes in pregnancy induced hypertension and to evaluate whether any specific morphological findings have consistent association with respect to its severity. Aim: To study the morphological features of placenta in toxemia of pregnancy and correlate these findings with respect to severity of pregnancy induced hypertension. Material & Methods: The present study was conducted in the Department of Pathology in collaboration with Department of Obstetrics and Gynecology, Teerthanker Mahaveer Medical College, Moradabad during February 2017 to September 2018. The cases were graded for degree of pregnancy induced hypertension, placental gross features and microscopic findings on routine hematoxylin and eosin staining. Result: Majority of cases had eclampsia (n=16; 64%). There were 7 (28%) cases diagnosed as preeclampsia and 2 (8%) as preeclampsia with superimposed eclampsia. Most of them (52%) wereyoung adults (20-25 years), from rural background (84%) and were nullipara (60%). 88% cases were anaemic. On gross examination 60% of placenta were circular in shape and rest were oblong with number of cotyledons ranging from 3 to 12.Histopathological changes in placenta and foetoplacental weight ratios (FPWR) showed a significant association with severity of anemia.FPWR was significantly lower in cases with eclampsia/PE with superimposed eclampsia as compared to those with preeclampsia. Amongdifferent histopathological features, presence of syncytial knots (84%) was most common finding. Conclusion: The findings of present study showed that morphological and histopathological changes take place in toxemia affected p