DOI: 10.36347/sjams.2019.v07i04.004

Pages: 1380-1384

Glucose-6-phosphate dehydrogenase deficiency is the most common clinically significant red blood cell enzyme defects in human biology. G6PD deficiency is an important risk factor for severe Neonatal hyperbilurubinamia NIH carries a substantial risk for harmful complications which include long-term neurologic impairments and death. In G6PD-deficent neonates, Proper management should be hastened to avoid irreversible neurological complications. This cross sectional study was carried out to observe the G6PD status in 90 male, term neonates with jaundice, age ranged from 3 to 12 days (Group B) in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University from 1st July 2007 to 30th June 2008. Our aim was to assess the treatment duration of neonates who have G6PD deficiency with jaundice. On the basis of total serum bilirubin level, study group was further divided into three groups: Group B1 (TSB <15mg/dl), Group B2 (TSB 15-20mg/dl) and Group B3 (TSB>20mg/dl). For comparison, age and sex matched 30 apparently healthy neonates (Group A) were also studied. Study group was selected from in patient and control group from outpatient department of Dhaka Shishu Hospital. Based on the severity of G6PD level with neonatal jaundice, Study group are admitted and observed with all others parameters including types of therapy, treatment duration, Blood grouping etc. Standard treatment protocol was followed like Phototherapy (PT) and exchange transfusion (ET). Identification and discontinuation of the precipitating agent is critical to manage hemolysis in patients with G6PD deficiency. Study suggested that treatment duration were significantly taking higher hospital stay in severe (p<0.01) groups in comparison to those of control, mild& moderate group .Erythrocyte G6PD levels were significantly lower in moderate (p<0.01, p<0.05) and severe (p<0.001, p<0.01) hyperbilirubinemic group in comparison to those of control and mild group. Based on severity, exchange transfusio