DOI: 10.36347/sjams.2019.v07i04.014

Pages: 1436-1439

The objective of the study is to evaluate the cardioprotective activity of etanolic bark extract of Terminalia catappa against Doxorubicin induced toxicity in laboratory animals. Terminalia catappa Linn belonging to the family Combretaceae, widely distributed in India. The parts of Terminalia catappa plant has traditionally used for various diseases. Literatures supports various extracts of leaves and bark of the plant have been reported to have anticancer, antioxidant, hepatoprotective, anti-inflammatory, antimicrobial and nephroprotective. The aim of the present study was to investigate the cardioprotective effect of ethanolic bark extract of Terminalia catappa against Doxorubicin induced toxicity in rats. The rats were divided into 5 groups of 6 animals each. Group I served as normal control administered with vehicle, Group II served as toxic control, administered with Doxorubicin (15mg/kg, bw) intraperitoneally as single dose on 7th day. Group III served as reference control, administered orally with Vitamin C (50 mg/kg, bw), Group IV and V administered orally with 200 and 400mg/kg of ethanolic bark extract of Terminalia catappa respectively. All the test drugs were administered once daily for 15 days by suspending in vehicle. On 16th day blood was collected under Pentobarbitone (45mg/kg, i.p) anaesthesia. The separated plasma was subjected to various biochemical tests like estimation of cardiac biomarkers Creatinine Phosphokinase and Lactate Dehydrogenase. The animals were sacrificed and heart tissue homogenate was subjected for the estimation Superoxide dismutase and Catalase. The results showed that, animals treated with 200 and 400 mg/kg of Terminalia catappa bark extract significantly decreased the cardiac biomarker enzymes Creatinine Phosphokinase and Lactate Dehydrogenase and increased the levels of Superoxide dismutase and Catalase. From the results it was concluded that, ethanolic bark extract of Terminalia catappa exhibits cardioprotective activity aga