DOI: 10.36347/sjams.2019.v07i04.019

Pages: 1465-1471

Carcinoma of the oral cavity is one of the most common malignant tumors worldwide, with major predominance in South-East Asia and India. In India, cancer of the oral cavity is one of the five leading sites of cancer. Objective– 1) To evaluate the expression of Ki67 & p53 in oral cavity & oropharyngeal Squamous Cell Carcinoma (SCC). 2) To correlate the result of IHC with tumor histological grade. Materials and methods: This was the prospective study carried out in Department of Pathology MAMC, Agroha on 50 cases of Oral Squamous Cell Carcinoma from period of February 2017 to March 2018. Bryne’s histological scoring was done and IHC with Ki67 and p53 was done on diagnosed cases. Result: Ki67 LI (Labelling Index) between the three histological grades showed that poorly differentiated group had the highest value and well differentiated had the least value. Ki67 LI increased with increase in histological grade of tumor. P53 LI between the three histological grades showed that poorly differentiated group had the highest value and well differentiated had the least value. The correlation between the parameters KI67 & P53 showed a good positive correlation, and was significant with a p value of <0.001. Conclusion: In conclusion, our result emphasized the importance of preliminary knowledge of the expression of P53 and Ki67 as a prognostic marker of survival in order to obtain the best chance for a cure for these tumors in terms of deciding the treatment option for these patients.