DOI: 10.36347/sjams.2019.v07i04.030

Pages: 1522-1527

Introduction: The diabetic foot infection is a frequent complication of diabetes. It is a major risk factor for amputation and remains among the leading causes of hospitalization of diabetics. Our work aims to determine the bacteriological profile of diabetic foot infection and to evaluate the resistance of the isolated bacteria to antibiotics. Patients and methods: We performed a prospective descriptive study from March 2016 to September 2017, including 170 patients hospitalized for diabetic foot infection at the military hospital in Marrakech. Results: We realized 170 samples of which 66% were deep and 33% were superficial. The isolation rate of Gram negative bacilli and Gram positive cocci were respectively 58.4% and 40.4%. The most common individual isolates were Staphylococcus aureus (20.2%), Escherichia coli (18%). Isolated enterobacterial strains were sensitive to amikacin and imipenem but insufficiently to ampicillin, ticarcillin, and amoxicillin-clavulanic acid. Gram-positive cocci expressed a high rate of resistance to penicillin G (92%). Vancomycin and fucidic acid were the most active antibiotics. The multi-drug resistant organism was representing 25.8% of isolates. Highly resistant bacteria have been isolated, consisting of 6 strains of carbapenemase-producing enterobacteria. Conclusion: The findings of this study demonstrated an alarming increase in the prevalence of antibiotic resistance of diabetic foot infection. Thus, it is imperative to rationalize the use of antibiotics, improve hygiene in hospitals and establish a system for continuous monitoring bacterial resistance.