DOI: 10.36347/sjams.2019.v07i04.039

Pages: 1562-1565

Context: Vitamin D status plays an important role in mineralisation of the skeleton at all ages. An alteration in vitamin D status and/or a reduced synthesis of 1, 25-dihydroxy vitamin D predispose to secondary hyperparathyroidism, which enhances bone remodelling and causes cortical bone loss. Aims: The present study was designed to evaluate: the prevalence of hypovitaminosis D in post-menopausal females and Relationship between vitamin D status in postmenopausal females with osteoporosis and without osteoporosis. Materials and methods: One hundred and forty-six post-menopausal women between 45 to 75 years attending the hospital OPD were studied. To be eligible for the study they had to have been post-menopausal for at least one year. The diagnosis of osteoporosis was made based on T-scores (BMD) at the lumbar spine (L1 to L4) and femoral neck by DEXA (GE Lunar Densitometer). Patients with chronic conditions affecting skeletal health and patients on drugs affecting the skeleton were excluded from the study. Serum 25(OH) vitamin D was estimated using LIAISON 25 OH Vitamin-D chemiluminescent immunoassay. Results: Out of 146 post-menopausal females, 100 subjects had vitamin D deficiency (≤ 20 ng/ml) and 29 subjects had vitamin D insufficiency (21 - 29 ng/ml). Thus, prevalence of hypovitaminosis D in post-menopausal females was 88.35%. Serum vitamin D was found to be significantly lower in post-menopausal women with osteoporosis as compared to post-menopausal women without osteoporosis (p< 0.05). On correlation analysis a positive correlation was noted between BMD and vitamin D, it was statistically significant. Conclusion: Serum vitamin D is a promising marker of bone turnover in post-menopausal women with osteoporosis, as it was found to be decreased in osteoporosis; therefore, it provides a dynamic measure of bone remodelling and it can be potentially useful in diagnosis and monitoring of response to therapy in patients of osteoporosis.