DOI: 10.36347/sjams.2019.v07i04.045

Pages: 1583-1587

Background: In spite of continuous improvement in database of existing knowledge on T2DM in children from pathologic point of view, the intimate mechanisms involving systemic inflammation, hyperglycemia and dyslipidemia in T2DM young patients. Aim: The present study was designed to determine the extent of systemic inflammation, glycemic and lipid profile in T2DM children and to determine their role in future cardiac complication. Materials & Methods: Fasting blood was collected and serum C – reactive protein (CRP) along with blood glucose, serum total cholesterol, triglycerides, HDL, LDL and VLDL levels were estimated by using standard methods in 20 children of either sex (07-16 years age group) suffering from T2DM (Group II) and in 20 normal healthy individuals, served as healthy controls (Group I). The observed values were expressed as Mean ± SD and data from patients and controls were compared using students‘t’ test. Result: Marked elevated levels of serum CRP (significantly high; p<0.05) was observed in T2DM children as compared to healthy controls. Similarly, blood glucose, serum total cholesterol, triglycerides, LDL and VLDL levels were significantly high (p<0.05) and serum HDL levels were significantly low (p<0.05) in T2DM patients as compared to healthy controls. Due to existence of systemic inflammation in combination with dyslipidemia and hyperglycemia, these metabolic alterations have been implicated in the development of future cardiovascular complication in young T2DM patients. Conclusion: Thus, regular screening of metabolic profiles, cardiac markers and systemic inflammation along with life style modifications are predictive and preventive measures which may help in reduction of T2DM complications and its burden in the growing young population.