DOI: 10.36347/sjams.2019.v07i05.010

Pages: 1719-1723

Background: Non-hodgkin Lymphoma (NHL) is a common killer throughout the world and a major percentage occur in extranodal tissue. Primary extranodal NHL has a varied presentation and is frequently associated with worse prognosis. Our study aims to evaluate clinicopathological profile of primary extranodal NHL presenting in our Institute over a period of 3years and study their immunohistochemical expression. Material/Methods: Total 223 cases of NHL during the period of January 2016 till December 2018 were evaluated retrospectively. Routine histology and complete panel of immunohistochemical analysis were done inside institute. Patient’s records were evaluated for haematological, biochemical, radiological, clinical presentation and staging. Results: 42.1% of all NHLs were extranodal, mean age of population were 54.2years. Male: Female ratio being 1.8:1. Most common age group affected was 6th decade, commonest histological pattern being diffuse large B cell Lymphoma (DLBCL). Most common site affected was gastrointestinal tract, of which commonest site of presentation was stomach. B cell: T cell lymphoma ratio was 4.53:1.Bone marrow involvement was seen in 6.3%of cases.Most of the patients had Ann arbor stage II. Conclusion: Extranodal NHL has a rising trend in developing countries. Due to improved diagnostic techniques many of them are being diagnosed early but needs targeted/site specific algorithm for adequate management. Studies/specific trials are lacking regarding zonal distribution, management and survival analysis. A holistic approach may help in containment of extranodal NHL disease burden.