DOI: 10.36347/sjams.2019.v07i05.022

Pages: 1802-1805

Infectious diseases remain a major cause of debility and death around the world and are responsible for worsening of living conditions of millions of people. Respiratory tract infection (RTI) is one of the most frequently reported infections worldwide and resulting in more than 50 million deaths every year attributed to both community-acquired and hospital acquired infection. This study has been conducted for duration of two year from January 2017 to December 2018, at Tripura Medical College and Dr. BR Ambedkar Memorial Teaching Hospital, a tertiary care referral centre of the state of Tripura, in North Eastern India. 161 patients participated in the study, of which 135 samples were culture positive and 26 samples showed no growth. Among the culture positive samples 122 (75.8%) samples showed bacterial growth. Female (60.9%) patients were significantly higher than males (39.1%). 95 (77.86%) numbers of the isolates were Gram negative bacilli, which included Klebsiella pneumonia (43.44%), Pseudomonas aeruginosa (24.59%) , E. coli (7.37%) , and Acinetobacter sp (2.45%). Gram negative bacilli shows that most of the isolates were sensitive to Amikacin (65.57%) followed by Imipenem (56.55%) and others. 27 (22.14%) isolates were Gram positive cocci, of which Methicillin Resistant Staphylococcus aureus (13.93%) was the predominant isolate followed by Streptococcus pneumoniae (7.37%) and Enterococcus faecalis (0.81%). Gram positive organisms were sensitive to Linezolid (81.48%), Levofloxacin (51.85%) and Ceftriaxone (48.14%) predominantly. The current scenario states that Klebsiella pneumoniae and Pseudomonas aeruginosa were the major causative agents of Lower Respiratory tract infection in this region of North East India and treatment in our centre need to be based upon the Antibiotic susceptibility test profile of the pathogenic isolate.