DOI: 10.36347/sjams.2019.v07i05.023

Pages: 1806-1809

General Anaesthesia with endotracheal intubation is the anaesthetic method of choice for many major and prolonged surgical interventions. The profound stress response associated with the performance of laryngoscopy and endotracheal intubation is often associated with deleterious effects in susceptible patient groups. Various drugs and methods have been studied for the attenuation of this reflex response to the procedure with varied results. The present study compared oral Pregabalin 150mg and a placebo given one hour before the procedure as premedication. The anaesthetic procedure was standardized in all the patients. Post-operative pain was managed with patient controlled analgesia with intravenous fentanyl. The rise in heart rate around the anaesthesia induction-intubation period was less in the pregabalin group compared to the placebo. Pregabalin significantly attenuated systolic, diastolic and mean blood pressures comparatively during laryngoscopy and intubation. Patients in the pregabalin group were found more sedated; however recovery profile was not found affected. Pregabalin significantly reduced post-operative fentanyl requirements. No major side effects were noted with the use of Pregabalin.