DOI: 10.36347/sjams.2019.v07i05.030

Pages: 1837-1842

Nephrotic syndrome is one of the most common glomerular disorders of childhood characterized by proteinuria that is severe enough to cause hypoalbuminemia and edema. A prospective observational study was done at Government General Hospital Kakinada over a period of 18 months to evaluate the clinical, biochemichal profile and outcome of nephrotic syndrome in children less than 14 years of age. Out of 36 children enrolled in the study anasarca is seen in all the cases with a mean albumin of 2.06 ± 0.3 mg/ dl, mean cholesterol is 342.5±101mg/dl and anaemia in 28 children (77%).35 cases (97%) are steroid sensitive and 1(3%) case is steroid resistant. Out of 35 steroid sensitive cases 2 cases turned out to be steroid dependent on followup. Nephrotic syndrome is a chronic disease with good prognosis. However most of the steroid sensitive cases during follow up become steroid dependent and are at risk of developing steroid toxicity .Availability of steroid sparing drugs greatly reduced the side effects associated with long-term usage of steroids. However good multicenter randomized control trials with large number of cases, followed up till adolescent age group are required to evaluate the therapeutic efficacy and safety profile of these agents.