DOI: 10.36347/sajp

Pages: 81-88

In this review we focus on the various features, drug loading technology and biomedical applications of resealed erythrocytes. Among the various carriers used for targeting drug delivery, erythrocytes constitute potential biocompatible carriers since they possess several properties which make them unique and useful carriers. They are biocompatible, biodegradable, possess long half lives, follow zero order release kinetics and can be loaded with a variety of biologically active compounds using various physical and chemical methods. Drug-loaded carrier erythrocytes are prepared by collecting blood sample from the organism of interest and separating erythrocytes from plasma. By using various methods (membrane perturbation, Electro-insertion, entrapment by endocytosis, Hypo-osmotic lysis) the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called “resealed erythrocytes”.