DOI: 10.36347/sjams.2019.v07i05.038

Pages: 1881-1883

Background: Strains of Klebsiella are responsible for a wide variety of diseases in humans; 1) Nosocomial infections [1] which have been well documented in India [2] 2) Respiratory tract infections 3) Acute pyelonephritis in pregnant women with urinary tract abnormalities such as urolithiases, hydronephrosis or congenital deformities 4) Sepsis (especially as mixed infections) 5) Secondary infections with other pathogenic bacteria [3] Multidrug resistant bacteria causes serious nosocomial and community acquired infections that are hard to eradicate by using available antibiotics. Methods: K. pneumoniae isolates which were confirmed by biochemical reactions during September - October 2014 were included in this study. The isolates were recovered from blood culture, pus, urine and sputum. Isolates were tested for antimicrobial drug sensitivity pattern. All clinical isolates were examined morphologically for Gram’s stain & colony characteristics on agar media. Result: In present study we found that 50% of isolates were multi-drug resistant, which matches with Archana et al. [8]. As per our statistical data, all confirmed K.pneumoniae isolates were resistant to Ampicillin, and only 1% & 3% were sensitive to Ampicillin-sulbactam and Cefotaxime respectively. Of 97 isolates, 19(19.58%) were found Extended spectrum beta-lactamase (ESBL) resistant. Conclusion: On the basis of our analysis we conclude that Tetracycline, Co-trimoxazol, Cefotaxime-clavulanic acid, Gentamicin, Cephalothin, Cefotaxime, Ceftaxidime were significantly resistant; Amikacin, Piperacillin, Aztreonam were relatively resistant; whereas Piperacillin-tazobactum, Meropenem, Levofloxacin, Nitrofurantion and Cefepime were not resistant. Antimicrobial resistance is a global concern not only because it delays cure but it increases health costs and threatens patient care [7]. Moreover, uses of broad spectrum antibiotics, insufficient aseptic precautions and techniques with inadequate control of infections spread h