DOI: 10.36347/sajp

Pages: 47-54

Various methods which are simple, sensitive and rapid are described for the estimation of salbutamol sulphate (SBS) in bulk drug and in tablet dosage forms using N-bromosuccinimide (NBS), bromate–bromide solution (BBS), four dyes, rhodamine-B and methylene blue, DONA & DPNA, as reagents and β-Cyclodextrin (BCD) as complexing agent. These methods allow semimicro and microlevel determination of SBS in authentic samples and in dosage forms. The methods were successfully applied to the assay of SBS in tablet and capsule formulations and the results were statistically compared. The accuracy and reliability of the methods were further accompanied by recovery experiments via the standard-addition technique.