DOI: 10.36347/sjams.2019.v07i06.032

Pages: 2194-2196

Introduction: Kidneys have an important role in the catabolism of thyroid hormones. Deiodination of T4 to T3 takes place mostly in the kidney. Since kidneys are the primary route for iodine elimination, advanced renal disease leads to increased plasma iodide pool because of decrease in renal clearance. Increased incidence of goiter has been reported in chronic renal failure due to defect in thyroid hormone synthesis Objective: To evaluate the thyroid hormone profile including T3,T4, TSH,FT3,FT4 in patients of CRF. Methods: In the present study thyroid function test in chronic renal failure attended at NRS Medical College and Hospital. The study was done on 50 patients of chronic renal failure. A group of 20 healthy volunteers was taken as control. All investigations (biochemical and thyroid function tests) were done. Results: Results obtained in patients with CRF was compared with those in the control group. Statististical analysis is done using student’s unpaired “t”test, p value <0.05 was taken significant. Conclusion: While comparing the cases and controls for T3, T4, FT3, FT4 and TSH values of T3, FT3 and T4 significantly decreased and values of TSH increased and approached to the higher side of the normal limit as creatinine clearance decreased. FT4 values did not show significant decrease with decreasing GFR. In this study decrease in T3, T4, FT3 and increase in TSH were found as creatinine clearance decreased the exact mechanism of this change with the decreasing renal function still not established. But the possible mechanism may be altered peripheral hormone metabolism, disturbed binding to carrier proteins, and possible reduction in tissue thyroid hormone content and increased iodine store in thyroid gland.