DOI: 10.36347/sjams.2019.v07i06.034

Pages: 2202-2206

Background: The aim of the study is to find Isosorbide Mononitrate as cervical ripening in terms of efficacy and safety. Method: In this study 100 pregnant women attending the antenatal clinics were evaluated and were selected for the study after applying inclusion and exclusion criteria.Women were counselled about the procedure, after taking consent. 40mg of isosorbidemononitrate inserted in the posterior fornix and second dose repeated after 6 hours. After insertion, the patients were monitored for uterine contractions, fetal heart rate. Monitoring of Maternal pulse rate, blood pressure. Oxytocin was started after 12hours, at the dose of 2 mu / min with increments of 2 mu/min every 30 minutes. Membranes were ruptured, when the cervix was fully effaced with a cervical dilatation of more than 3 cms. If bishop score is not changed after 24 hours of insertion, it was considered as induction failure.Patients were taken for caesarean section if signs of fetal distress appeared. Result: In our study significant change in Bishop’s score, fewer requirements of oxytocin, and short induction delivery interval was found in IMN group, whereas adverse effects like Tachysystole, Hyperstimulation and admission to NICU were less in IMN group. Conclusion: IMN is cheaper and effective alternative to dinoprostone for cervical ripening and induction of labour at term despite its shortcomings and those women who do not respond to IMN must be given a trial with intracervical PGE2 gel for which further studies are required.