DOI: 10.36347/sajp

Pages: 74-80

The methanol extract of Achyranthes aspera Linn. (Family- Amaranthaceae) the herb was studied for its Phytochemical and some Pharmacological activities. The study of the herb extracts indicated the presence of flavonoides, tannins, saponins, and alkaloids. The pharmacological study includes thrombolytic and cytotoxic activity. They showed significant cytotoxic effect in Brine shrimp lethality bioassay where the plant extracts exhibited LC50 =3.80µg/ml and LC90 =7.04µg/ml (after 18 hour); LC50 =3.31µg/ml and LC90 =6.36µg/ml (after 21 hour); LC50 =2.18µg/ml and LC90 =5.29µg/ml (after 24 hour). This study gave a significant indication to the use of the plant extract as a potential source for cytotoxic compounds. In the thrombolytic activity of standard was found 76.08% and for A. aspera was 36.49%, which indicates moderate thrombolytic activity. Based on the findings of thrombolytic and toxicological activity, we can say that Achyranthes aspera may contain some novel compounds that possess potent anti-mutagenic activity and clot lysis property