DOI: 10.36347/sajp

Pages: 101-106

Ophthalmic formulations in the form of insitu gel system can be applied as solution or suspension that undergoes gelation after administration. Diclofenac Pottasium is one of the commonly used nonsteroidal antiinflamatory drug usually for the treatment of inflammation. Insitu gel formulation of diclofenal potassium ophthalmic drug delivery system used to reduce the inflammation caused by various diseases as well as to prevent postoperative inflammation in cataract surgery. Insitu gel formulation of ophthalmic delivery of diclofenac was fabricated using sodium alginate and hydroxy propyl methyl cellulose in different concentrations under aseptic conditions. Various evaluation tests as well as stability testing of formulations were carried out to identify the ideal formulation.From the parameters,the ideal formulation was identified, that having the polymer combination of Sodium alginate and Hydroxy propyl methyl cellulose in the ratio of .Thus the formulation canbe utilized for its sustained release property that may improve patient compliance.