DOI: 10.36347/sjams.2019.v07i07.023

Pages: 2383-2391

HIV is a public health issue that has disturbed the existence of mankind especially in the developing countries. A study to evaluate the levels of interferon-gamma, interleukins 6 and 10, hepcidin, iron status and some haematological parameters in non ART HIV positive subjects was carried out. A total of 100 subjects aged 18-60 years were enlisted for this study. The subjects were grouped into: Group A (50 control subjects) and Group B (50 were non ART HIV subjects). About 4.5ml of blood were collected into plain tubes for assay of interferon gamma, interleukins (6 &10), hepcidin and iron and 2.5ml for FBC, CD4 count and HIV screening. The cytokines and hepcidin were measured using MELSIN ELISA Kits and Teco Diagnostics kits used for iron determination. Full blood count was determined by automation using Mindray BC-5300.The data was analysed with the statistical package for social science (SPSS) version 20 using ANOVA and Pearson Product Moment method were statistical tools for the analysis and the level of significance set at P<0.05.The results showed difference that was statistically significant (P<0.05) in IFN-γ (16.25±0.87pg/ml, 29.31±1.44pg/ml, P=0.000), IL-6 (7.98±0.22pg/ml, 11.08±1.21pg/ml, P=0.000) IL-10 (8.52±0.62pg/ml, 16.62±1.53pg/ml, P=0.000), CD4 (1045.54 ±247.24Cells/L, 195.60 ±35.94Cells/L, P=0.000), hepcidin (6.03±1.38ng/ml, 39.59 ±4.50ng/ml, P=0.000), Iron (86.29±7.27 µg/dl, 73.43±5.45 µg/dl, P=0.000), TIBC (345.56±28.40 µg/dl, 287.19 ±8.21µg/dl, P=0.000), WBC (5.87 ±0.88 X 109/L, 4.69±0.72X 109/L, P=0.000), Neutrophils (60.57±2.83%, 75.16±3.68%, P=0.000), Lymphocytes (30.69 ±2.84%, 17.24±2.50%, P=0.000), Monocytes (5.59 ±1.2%, 4.18±1.12%, P=0.000), Basophil 0.86 ±0.39%, 1.31±0.94%, P=0.003), RBC (4.92±0.30 X 1012/L, 3.34±0.21 X 1012/L, P=0.000), Haemoglobin (14.75±0.90,g/dl, 10.05±0.65g/dl, P=0.000), PCV (44.25±2.70%, 30.14±1.95, P=0.000), MCV (89.92±2.3fl, 79.49±1.28fl, P=0.029), MCH (36.12±1.53pg, 26.60±0.48Pg, P=0.000), MCHC (368.46±12.28g/l, 3