DOI: 10.36347/sjams.2019.v07i07.026

Pages: 2399-2403

The prevalence of hypertension is increasing nowadays and treatment of hypertension will result in decreasing the morbidity, mortality and prevent target organ damage. The present study was done to find the efficacy and safety of Angiotensin Converting Enzyme Inhibitors Angiotensin II Receptor blockers in Essential Hypertension patients. Methods: This prospective and analytical study was done in the Essential Hypertension patients attending, Department of General Medicine, Mahatma Gandhi Memorial Hospital, Kakatiya Medical, College, Warangal. A total of n=60 patients were taken with the diagnosis of Essential Hypertension they were divided into two groups. Group I were n=30 (Enalapril) they were given (Tab Enalapril) 5mg OD, and group II n=30 (Tab Losartan) 50mg OD. An overnight (8 hours) fasting blood sample of 10 ml was obtained from the anti-cubital vein under aseptic conditions in a vacutainer. The biochemical parameters were analyzed by semi auto-analyzer. Results: The renal parameters were measured for the group I (Enalapril) at the start of the treatment and during various follow-ups. There was a slight decrease in serum creatinine from the beginning of the study and at the end of 6 months however, the p values were not found to be significant. The values of parameters in group II (Losartan) were recorded in the present study. The values of blood urea decreased slightly at during the period of study however, it was not found to be significant. The values of serum potassium were found to be increased significantly at the end of 6 months. The mean blood pressure parameters were recorded at the beginning of the study and at the end of 6 months the values of systolic blood pressure were found to be less in group II Losartan, however, the values were not found to be significant. The diastolic blood pressure has shown a greater decrease in the Losartan group and the values were found to be significant. Conclusion: The present study shows that there are overall bett