DOI: 10.36347/sjams.2019.v07i07.031

Pages: 2432-2436

Background: Cytokeratin 5/6 expression by basal/myoepithelial cell in epithelial breast lesion can be used to identify myoepithelial cells. Methods: In the present study immunohistochemical staining for cytokeratin 5/6 was done on 51 cases of malignant epithelial breast lesions by using avidin biotin peroxidase technique on paraffin embedded sections. Distribution and intensity of immunostaining for cytokeratin 5/6 in various malignant breast lesions were recorded. Result: Among 51 malignant breast lesions, 12 cases (23.52%) showed positive immunostaining with cytokeratin 5/6 with staining index ranging from 2-7, 1 case of Ductal carcinoma in situ which show negative immunostaining with cytokeratin 5/6 and 5 out of 8 cases (62.5%) of triple negative infiltrating carcinoma showed positive immunostaining with cytokeratin5/6. Conclusion: Cytokeratin 5/6 antibody is used to detect basal like carcinomas in malignant breast lesions to correlate with the prognosis and treatment of breast carcinoma.