DOI: 10.36347/sjams.2019.v07i07.054

Pages: 2544-2548

To study the effectiveness of Dexmedetomidine in the dose of 1 µg/kg to attenuate the pressor response to laryngoscopy and endotracheal intubation, 100 patients posted for elective surgery under general anesthesia were selected for this double blinded prospective study with inclusion and exclusion criteria and after institutional ethical committee approval and informed consent from the patients, the eligible patients were divided into two groups 50 in each. Group(S)-Received normal saline and 10 minutes before the induction, the patients were given 100ml of NS over 15 minutes. Group (D)-Received dexmedetomidine and 10 minutes before the induction, the patients were given Inj.Dexmedetomidine 1 µg/kg in 100 ml of normal saline over 15 minutes. After receiving the drug, patients were monitored. All the patients were premedicated and same anaesthetic agents were used for conduction of general anaesthesia in all patient. Laryngoscopy was performed gently by an experienced anaesthesiologist in less than 15 seconds and intubated while monitoring the blood pressure, pulse rate, and E.C.G. This study was concluded that patients in Group-D (Dexmedetomidine) had better control of hemodynamic changes during laryngoscopy and endotracheal intubation than the Group-S(Saline) without any side effects.