DOI: 10.36347/sjams.2019.v07i07.055

Pages: 2549-2552

The active form of Vitamin D has endocrine effects on bone as established by its crucial requirement in bone mineralization. Deficiency causes rickets in children, Osteomalacia or Osteoporosis in adults. Low Vitamin D status has been detected in patients with hip fractures. Vitamin D, along with Parathyroid hormone affects bone mineralization. Our study is aimed at correlating the relationship between 25- hydroxyvitamin D, Parathyriod hormone (PTH) and bone mineral density (BMD) in cohort of South Indian population. The Bone mineral density of 60 pre- menopausal and 60 post-menopausal women was compared with Vitamin D and Parathyroid hormone status. BMD of hip and spine were derived from dual energy X-ray absorptiometry. Vitamin D and Parathyroid hormone were assayed by Electro chemiluminescent methodology. Multivariate regression models were employed to investigate the relation between Bone mineral density with Vitamin D and Parathyroid hormone. The average age of pre- menopausal and post-menopausal women is 39 ± 8 years & 57 ± 7 years respectively. The mean values of serum Vitamin D and PTH among premenopausal women were 19 ± 9 ng/mL and 47±18 pg/mL respectively. And the mean value of serum Vitamin D and PTH among post-menopausal women were 19 ± 11 ng/mL and 49±16 pg/mL respectively. Among the post- menopausal women 25 were osteopenic and 31 were osteoporotic whereas among the pre- menopausal women 25 were osteopenic and 10 were osteoporotic. There exist a negative correlation between Vitamin D and Parathyroid hormone, positive correlation between Vitamin D and Bone mineral density and negative correlation between Parathyroid hormone and Bone mineral density. Parathyroid hormone showed a significant negative correlation with Bone Mineral Density at hip and lumbar spine. This signifies the critical role of Parathyroid hormone in maintaining normal bone mineralization.