About Us   |   Contact Us
An International Publisher for Academic and Scientific Journals
Author Login 
 Author Login
Submit Manuscript
Join Membership
Join As Reviewer
Join As Editor
Pay Publication Fee
Subscribe Hard Copy
Scholars Academic Journal of Pharmacy | Volume-2 | Issue-02
One Pot Synthesis of Pyrido [1,2-a]Pyrimidine Derivatives and Screen their Biological Properties
Vartale S.P, Halikar N.K, Jadhav A.G, Chavan S.B, Patwari S.B
Published: Feb. 28, 2013 | 191 145
DOI: 10.36347/sajp
Pages: 130-134
Downloads
Abstract
The ethyl 2-cyano-3,3-bis(methylthio)acrylate (1) on treatment with 2-amino pyridine (2) in ethanol and catalytic amount of TEA, gives 3-cyano-7-methyl-4-oxo-2-(methylthio)-4H-pyrido[1,2-a]pyrimidine(3).The latter were further reacted with selected N-,O-,and C- nucleophiles such as aryl amines, hetryl amines, substituted phenols and compounds containing an active methylene groups.