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Scholars Academic Journal of Pharmacy | Volume-2 | Issue-02
One Pot Synthesis of Pyrido [1,2-a]Pyrimidine Derivatives and Screen their Biological Properties
Vartale S.P, Halikar N.K, Jadhav A.G, Chavan S.B, Patwari S.B
Published: Feb. 28, 2013 | 64 90
DOI: 10.36347/sajp
Pages: 130-134
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Abstract
The ethyl 2-cyano-3,3-bis(methylthio)acrylate (1) on treatment with 2-amino pyridine (2) in ethanol and catalytic amount of TEA, gives 3-cyano-7-methyl-4-oxo-2-(methylthio)-4H-pyrido[1,2-a]pyrimidine(3).The latter were further reacted with selected N-,O-,and C- nucleophiles such as aryl amines, hetryl amines, substituted phenols and compounds containing an active methylene groups.