DOI: 10.36347/sjams.2019.v07i07.065

Pages: 2595-2598

Introduction: Breast cancer is the most common cancer in Bangladeshi women. Locally advanced breast cancer is a clinical challenge which represents a wide range of clinical scenario. Including large primary tumor (Stage T4). Advanced nodal disease (Fixed axillary lymph nodes; or involvement of ipsilateral supraclavicular, infraclavicular or internal mammary nodes) and inflammatory carcinoma. Women with LABC require multimodal therapy and coordinated treatment approach to optimize patient care. Aim: The aim of our study was to determine various mode of presentation of patients in clinical practice, to justify various methods of treatments given, response of patients to neoadjuvant chemotherapy and along with possible outcome of our treated patients. Materials & Methods: Total 36 patients were selected based on histopathological diagnosis of LABC, who came to our private clinic in the time span of 2011-2016. Cases are reviewed on basis of their clinical presentation, re-investigation findings to exclude metastases; histopathological reports reviewed & TNM status determined for individual patients. Including receptor status assessment. We assess the response of patients to preoperative chemotherapy & review the treatment & follow-up records. Results: Among 36 patients 29.5% were in 31-40 years age group. 11 patients (25%) were in 41-50 years age group. Seven (16%) patients were (51-60) years age groups. 5 (11.3%) patients were 61-70 years age group. 100% patients presents with breast lump which are self-detected due to large size. 27 (75%) patients present with nipple retraction skin ulceration in 7 (19.4%) patients satellite nodules 3 (8.33%) patients. Skin oedema 3 (8.33%) patients. Mobile ipsilatral axillary lymphanode in 17 (47.2%) fixed ipsilatral axillary lymphanode 14 (38.7%) patients. No patient has distant metastasis at presentation. 29 (80.5%) patients sent for preoperative chemotherapy 7 (19.4%). Patients underwent operative treatment as their initial modal