DOI: 10.36347/sjams.2019.v07i08.011

Pages: 2682-2689

Background: Psoriasis is associated with altered pulmonary function. Methotrexate affects the lung function status in psoriatic patients: effect of other antipsoriatic medication on lung function was not evaluated. Hypothesis: Antipsoriatic medication affects the lung function status in Psoriatic patients. Objectives: To assess the lung function status in diagnosed male psoriatic patients after antipsoriatic medication. Method: This cross-sectional study was carried out in the Department of Physiology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, from July 2012 to June 2013. A total number of 120 subjects were selected, among which 30 were apparently healthy subjects (control group-A) for comparison and 90 were diagnosed male Psoriatic patients (study Group-B). Controls were selected from the community and the patients from the Indoor and Out Patient Department (OPD) of Dermatology and ventilatory, BSMMU, Dhaka. Based on treatment, these study subjects were further divided into three groups consists of 30 male subjects in each group. These were group B1 (30 diagnosed male Psoriatic patient receiving only topical therapy), B2 (30 male Psoriatic patients receiving PUVA therapy, B3 (30 male Psoriatic patients receiving Methotrexate therapy). The medication was prescribed by physicians of Dermatology and Venereology, Indoor and OPD of BSMMU. Age of all the participants were ranged from 25-45 year and they were matched in terms of age, sex, BMI, occupation and socio economic status. All the lung functions were assessed by measuring FVC, FEV1, FEV1/FVC ratio, PEFR, FEF25-75%, FEF25%, FEF50% and FEF75% with a RMS computer based Spirometer. For statistical analysis Independent sample‘t’ test, ANOVA, Chi-square and Pearson’s correlation coefficient test were performed, as applicable. Results: The mean percentage of predicted values of lung function variables in healthy male subjects were within normal ranges. Almost all the ventilatory vari