DOI: 10.36347/sajp

Pages: 160-167

The present work is aimed at preparing and evaluating sustained release matrix tablets of Lamivudine using different polymers and polymer combinations. Matrix tablets were prepared by direct compression method taking Carbopol, Ethyl Cellulose, Chitosan, Guar Gum, and Xanthan Gum as polymer as different composition and M1 to M10 total ten formulation were prepared. The powder are evaluated for flow properties and tablet were evaluated for hardness, friability, dissolution rate, kinetics studies etc. In result it was found that the formulation containing Carbopol, Chitosan, Ethyl Cellulose, and HPMC combinations controlled the drug release better than the compositions with Guar Gum and Xanthan Gum combinations