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Scholars Academic Journal of Pharmacy | Volume-2 | Issue-03
Formulation and Evaluation of Sustained Release Lamivudine Matrix Tablets
M. Puli Singh, Md. Arshiya, J. Anand, Allam Vamshikrishna, Sai Krushna Padhy
Published: March 30, 2013 |
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80
DOI: 10.36347/sajp
Pages: 160-167
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Abstract
The present work is aimed at preparing and evaluating sustained release matrix tablets of Lamivudine using
different polymers and polymer combinations. Matrix tablets were prepared by direct compression method taking
Carbopol, Ethyl Cellulose, Chitosan, Guar Gum, and Xanthan Gum as polymer as different composition and M1 to M10
total ten formulation were prepared. The powder are evaluated for flow properties and tablet were evaluated for hardness,
friability, dissolution rate, kinetics studies etc. In result it was found that the formulation containing Carbopol, Chitosan,
Ethyl Cellulose, and HPMC combinations controlled the drug release better than the compositions with Guar Gum and
Xanthan Gum combinations