DOI: 10.36347/sjams.2019.v07i08.042

Pages: 2835-2846

Osteoporosis is a skeletal disorder characterized by reduction of bone mineral density (BMD) and bone strength leading to increased risk of fractures. Many secondary factors may contribute to the bone fragility or osteoporosis. The current study evaluates the effect of avocado and flaxseed oils and their synergetic effect on the secondary osteoporosis induced by glucocorticoid treatment. For this purpose, this study conducted on Sixty female albino rats were divided into 2 main groups; healthy and osteoporotic groups. Osteoporotic rats were treated with 6mg prednisolone/kg body weight daily for three weeks, then subdivided into five subgroups, each subgroup consisted of 10 rats as follow; 10 rats served as osteoporotic rats, 10 rats served as osteoporotic rats fed on Calcium (Ca) supplement (7g calcium carbonate/ kg diet). 10 rats of osteoporotic rats fed on normal diet containing 4% avocado oil with Ca supplement, 10 rats of osteoporotic rats fed on normal diet containing 4% flaxseed oil with Ca supplement. Finally, 10 rats of osteoporotic rats fed on normal diet containing 4% both oils mixture with Ca supplement. The obtained data revealed that, glucocorticoid treatment caused significant reduction in BMD, bone mineral content (BMC), bone formation markers as serum osteocalcin (OC), alkaline phosphatase (ALP) and estradiol (E2) levels and significant increase in bone resorption markers as acid phosphatase (ACP) and parathyroid hormone (PTH) levels. Also, significant increase in Ca and phosphorus (P) bone resorption and urine excretion indicating the onset of osteoporosis. Whereas, feeding of osteoporotic rats by Ca supplement with avocado or/and flaxseed oils caused significant elevation in BMD and BMC indicated by significant improvement in the levels of serum, urine and bone Ca and P levels and bone formation markers with significant reduction in bone resorption markers........................