DOI: 10.36347/sjams.2019.v07i08.048

Pages: 2868-2872

Ischemic Heart Disease is the most common cause of cardiovascular mortality. Early detection of Acute Myocardial Infarction (AMI) at the ischemic stage is important to prevent morbidity and mortality. Heart type Fatty Acid Binding Protein (H-FABP) is a sensitive indicator of ischemia, increases earlier than other cardiac markers. With the above view, the study aimed to determine the efficacy of H-FABP in the early diagnosis of Myocardial Infarction (MI) and its correlation with Creatine Kinase –MB isoform (CK-MB) and fasting Lipid Profile. This age matched cross sectional study was conducted in a tertiary health care Centre. 90 subjects were included with age limit of 30 to 60 years. 45 cases were selected from patients admitted in ICCU within 6 hours of complaints of chest pain and 45 healthy individuals as controls. The Mean value of HFABP and CK-MB in cases were higher than the controls and the p values were 0.000 (<0.05) which are statistically significant. When compared to CK-MB, HFABP showed 76.5% detection of myocardial ischemia in the first 3 hours of symptoms, whereas CK-MB had only 58.8%. Positive correlation was also found between HFABP and duration of chest pain. Though we had significant difference in Lipid profile between cases and controls, no correlation was found with HFABP value. In this study, elevated HFABP in the early hours (0 to 3 hours) of onset of ischemic chest pain clearly shows that serum HFABP can be used as an early marker in the diagnosis of coronary artery disease.