DOI: 10.36347/sajp

Pages: 173-179

Cardioprotective role of Commiphora wightii (guggul) were investigated by monitoring biochemical parameters in high fat diet induced hyperlipidemic male albino rats. The hyperlipidemic rats co-administered with 400mg/kg bw ethyl acetate extract of Commiphora wightii resins (EACWR) for 45 days. Enzymatic, non-enzymatic antioxidants, lipid peroxidation, protein oxidation, nitrate and inflammatory markers (CRP, COX, XO) were investigated. Increased level of lipid peroxidation, protein oxidation, XO, CRP and COX whereas decreased level of SOD, CAT, GSH, GPx, GR, nitrate level were observed in cardiac tissues of hyperlipidemic rats whereas restoration of above parameters towards normalcy were found in EACWR treated hyperlipidemic rats. Improved endothelial lining and cardiac function is attributed to enhance NO bioavailability due to EACWR treatment and represents a pharmacological approach to prevent major complications associated with oxidative burden and inflammation as a result of hyperlipidemia in cardiovascular disorders.