DOI: 10.36347/sjams.2019.v07i09.003

Pages: 2931-2935

This was a prospective descriptive type study conducted in the Department of Pharmacology and Therapeutics in collaboration with the Department of Dermatology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh during the period from July 2014 to June 2015. The aim of the study was to measure the lipid peroxidation product malondialdehyde (MDA) as a marker of oxidative stress in psoriasis patients in the treatment process. Psoriasis is a chronic inflammatory, proliferative skin disease considered as compulsive skin lesions due to various exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. A total of 26 clinically diagnosed psoriasis patients were included in this study. Clinically diagnosed psoriasis patients of both sexes who came for first treatment purposes in Dermatology OPD of Rajshahi Medical college hospital were included in this study. Newly diagnosed psoriatic patients who fulfilled the inclusion criteria were also included in this study. The data was expressed as mean ± standard deviation. Paired t- test was employed for the statistical analysis of data. P- value less than 0.05 was taken as significant. Pre-treatment the MDA level of 15 clinically diagnosed mild psoriasis patients was 3.00±0.45 µmol/l which was decreased to 2.83±0.52 µmol/l after conventional treatment with topical corticosteroid and oral vitamin A for one month. This decreased level was statistically highly significant (P<.001). Post-treatment, the MDA level of 11 clinically diagnosed severe psoriasis patients was 3.89±1.17 µmol/l which was decreased to 2.50±1.03 µmol/l after conventional treatment with oral methotrexate, vitamin A and topical corticosteroid for one month. This decreased level was statistically highly significant (P<.001).From the reflection and outcomes of the present study, it is revealed that after conventional treatment for one month showed the plasma MDA level which is the product of lipid peroxidation