DOI: 10.36347/sjams.2019.v07i09.008

Pages: 2954-2957

Aim: To initiate highly active antiretroviral therapy (HAART) there is uncertainty about the optimal time for human immunodeficiency virus (HIV) infected adults suffering from tuberculosis (TB) as antiretroviral therapy (ART). The main aim of this trial to evaluate the Effect of Early Initiation of Antiretroviral Therapy in for Indian HIV-Infected individuals with tuberculosis. Methods: This is an observational prospective trial done at Patna Medical College and hospital, patna, Bihar. HIV infected adults suffering from tuberculosis (TB) were randomly assigned to receive HAART after 2-4 weeks of starting ATT, and were followed for 12 months after HAART initiation. Directly observed therapy short course (DOTS) for TB were received by the all participant. This patients were also received antiretroviral regimen which include stavudine or zidovudine, lamivudine, and efavirenz. Progression of HIV disease marked by failure of ART and death from any cause were the primary end points. Result: 88 patients were included in this trial and there was very less no of mortality and incidence of ART failure. Survival at 12 months was 93%. There were very less adverse events observed during the followup period. The incidence of immunological failure was seen to be significantly lower among which Virological failure documented in 6 patients. Rate of overall treatment failure was also significantly low which was as low as only 6%. Conclusion: Patients with HIV and TB Early initiation of HAART significantly decreases incidence of HIV disease progression and has good tolerability.