DOI: 10.36347/sjams.2019.v07i09.009

Pages: 2958-2961

Aim: Understanding of clinical profile and magnitude of pediatric HIV is essential for the policy makers and clinicians. Main objective of the study is to evaluate the prevalence rate of seropositivity among HIV infected patients with high risk clinical profile. Method: 302 patients with high risk clinical profile for HIV seropositivity and aged between 18 to 58 years were recorded over almost 1 year for this hospital based prospective observational clinical study. Data were maintain in a predesigned pro forma. Informed consent was taken from the patients before enrolling them into the trial. Result: Majority of the patients were belongs to in between 23 to 35 years 67% followed by 35 to 50 years (21%) and >50 years (12%). Failure to thrive in 239 (82%) was the most commonest clinical features associated with high risk profile along with chronic diarrhoea in 94 (31%), persistent fever in 175 (58%) and cough >1month 118 (39%) of 302 patients who were screened. It has been also observed that nutritional problem like malnutrition is also a major clinical manifestation as almost 178 (59%) subjects were affected with it. Oropharyngeal candidiasis, Generalized lymphadenopathy, repeated systemic infections and seborrhoeic dermatitis were present in 14 (5%), 34 (11%), 15 (5%) and 11 (4%) patients respectively. chronic diarrhoea was a significant independent clinical risk factor for predicting HIV seropositivity. Patients with chronic diarrhoea were at 11.15 times greater risk of being HIV seropositive compared to those who did not have diarrhoea. Conclusion: Number of clinical manifestation present determine probability of HIV infection. Vertical transmission in this study indicating HIV positive parents.