DOI: 10.36347/sjams.2019.v07i09.022

Pages: 3017-3021

Introduction: Bangladesh is an intermediate endemic country for hepatitis B, with a huge burden of CHB patients. Early diagnosis and treatment can reduced the adverse sequlae of CHB. The aim of the study was carried out to evaluate the serum hyaluronic acid level as a non-invasive marker of hepatic fibrosis in chronic hepatitis B. Objective: To find out Correlation between serum hyaluronic acid level and liver fibrosis in patients with chronic hepatitis B. Methods: Enrolled patients for study were divided into two groups, Group-1, 40 patients with chronic hepatitis B. Group -2, thirty age and sex matched patients without fiver disease was served as control. Study was done in the department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, during the period of July 2007 to June 2009. We included patients with chronic hepatitis B characterized by, HBsAg positive for more than 6 months, HBeAg positive or negative, serum HBV DNA in PCR (more than 105 copies/ml in HBeAg positive or more than 104 copies/ml in HBeAg negative case), serum ALT normal or elevated and excluded the patients who were decompensated cirrhosis, co-infection with hepatitis C virus, with history of alcoholism, with anti HBV therapy, drug induced hepatitis, sonologic evidence of NAFLD and patients with rheumatological disorder..................