DOI: 10.36347/sjams.2019.v07i09.025

Pages: 3035-3040

Intraoperative nausea and vomiting (IONV) causes distress to the patient and may interfere with the surgery. Intraoperative nausea and vomiting or postoperative nausea and vomiting (PONV) affecting women undergoing regional anesthesia for cesarean section is an important clinical problem since these techniques are used widely. There are burdens of literature about IONV and several in parturient and cesarean. However, it needs more attention. The main objective of the study was to evaluate the effectiveness of ondansetron and ketamine for prevention of intraoperative nausea and vomiting in caesarean section under spinal anaesthesia. Spinal anaesthesia is considered as gold standard for caesarean section due to its advantages of rapid and predictable onset, no airway handling, safer to mother and minimal drug exposure to fetus. But spinal anaesthesia caesarean section is associated with high incidence of IONV. Role of ondansetron as antiemetic is well established. Not many studies are there for ketamine in prevention of IONV. This comparative study was conducted in the department of Anesthesiology collaboratively with the department of Obstetrics in Ashiyan Medical College Hospital, Barua Khilkhet, Dhaka, Bangladesh during the period from January 2018 to December 2018. A total of 240 pregnant patients scheduled for CS under spinal anaesthesia were included as the total study population and divided into 2 groups. In Group I, there were 120 patients who received ketamine; in Group II there were 120 patients who received ondansetron. The patients were compared for intraoperative hemodynamic parameters, IONV, side effects like sedation and shivering. In the results we found the incidence of intraoperative nausea and vomiting (IONV) was 24% and 32% in Group I (Ketamine group) and Group II (Ondansetron group) respectively.