DOI: 10.36347/sjams.2019.v07i09.034

Pages: 3077-3082

Introduction: Alpha1-Adrenoceptor antagonists are now well established as the most common treatment for lower urinary tract symptoms (LUTS) suggestive of bladder outflow obstruction associated with benign prostatic hyperplasia (BPH). We compared the incidence of postural hypotension symptoms BPH treated with tamsulosin or alfuzosin. Material and methods: A single centre, open label, double arm, observational study to evaluate International Prostatic Symptom Scored (IPSS) LUTS scores, quality of life (QoL), Maximum flow rate (Qmax) and post void residue (PVR) from baseline at 1st day, after 1 month and 2 after months. The secondary endpoints were ADE to the drugs. This is comparative study was conducted on patient attending urology department with BPH. A total number of 60 patients were divided into two arms, one arm received Tamsulosin (10mg) and the other arm received Alfuzosin (0.4mg). The study design was mainly based on the analysis of questions answered by each patient for the occurrence of the symptoms. Patients were enrolled in this study according to the following Inclusion/Exclusion criteria. Results: During the analysis of the study, the data generated showed that the percentage IPSS, QOL, Qmax and PVR showed significant improvement in Alfuzosin after 1 & 2 months. Adverse drug events (ADE) were observed in 45% (27/60) patients, most importantly occurrence of postural hypotension symptoms was found to be more in subjects treated with Alfuzosin as compared to that of Tamsulosin. The various postural hypotension symptoms observed were dizziness, bodily dissociation, lightheadedness, nausea, headache, blurred or dimmed vision and fainting. Conclusions: It was found that Tamsulosin and Alfuzosin were both well tolerated. In the present study, most efficacious Alfuzosin with rapid onset of action....................