DOI: 10.36347/sjams.2019.v07i09.045

Pages: 3143-3148

Children with Nephrotic syndrome while in nephrosis commonly have a state of mild or subclinical hypothyroidism although they are clinically euthyroid. Loss of thyroxine (T4) and thyroxine binding Globulin (TBG) leads to decrease in total T4 and increase in TSH.A prospective observational study was conducted in children with Nephrotic syndrome over a period of 18 months from January 2013 to June 2014. Objective: To compare the thyroid function of Nephrotic children during nephrosis with that in remission and with healthy controls. Methods: 40 Nephrotic Children between 3-12 years of age in initial episode or in relapse were enrolled in this study. Their thyroid function (Serum FT4, TSH and Thyroglobulin) during nephrosis and while in remission was compared with age-matched healthy controls. Results: Mean age of study population was 83.8 +/_34.21months compared to 83.18 +/_36.6months in controls. Male: Female ratio was 1.8:1. Mean value of serum FT4 in children during nephrosis was 1.17±0.24 μg/ml and was comparable to the control population (1.16±0.14 μg/ml). Serum TSH in nephrosis was higher than controls {Median (range): 3.08 (90.61-20.00) Vs 1.75 (0.12-6.36) MIU/L,P-0.008}.Serum Thyroglobulin was significantly higher in Nephrotic children in comparison to controls (Median (range):86.56 (5.34-206.50) Vs 17.18 ng/ml (1.36-134.2), P -0.001}.Comparison of thyroid status (Serum FT4, TSH and Thyroglobulin) during nephrosis and while in remission showed no significant difference in FT4 but TSH was significantly high in nephrosis as compared to in remission {Median (range):3.08 (0.61-20) Vs 1.65 (0.45-6.08) MIU/L, P -0.001}.Thyroglobulin is significantly elevated during nephrosis and it became normal in remission (Median (range): 86.56 ng/ml (5.34-206.50) Vs 39.87 ng/ml (1.32-212.0) P 0.002}. Thyroglobulin showed significant negative correlation with serum albumin (P-0.03) and positive correlation with protein excretion..................