DOI: 10.36347/sjams.2019.v07i09.061

Pages: 3216-3219

Background: Type 2 diabetes mellitus (T2DM) is not confined only to adults but its prevalence in children and adolescents is in alarming proportion. In this context, appearance of morphological manifestations along with biochemical alteration play a crucial role in diagnosis of disease. Aim: The aim of present study was to ascertain the appearance of Acanthosis Nigricans (AN) and its relation with insulin resistance and body mass index (BMI) in children and adolescents with T2DM. Methodology: 25 patients of either sex (08-18 years age group) suffering from T2DM and 25 normal healthy individuals as controls; were included in the study. AN was checked on the skin of the intertriginous areas in T2DM patients. Homeostasis model assessment for insulin resistance (HOMAIR) was calculated along with estimation of glycemic profile using standard methods and data from patients and controls were compared by using Chi square-test and student t-test. Result: Marked appearance of AN was observed along with significantly high (p<0.001) levels of serum insulin and fasting blood glucose levels in T2DM patients as compared to healthy controls. In addition, AN was directly associated with enhanced insulin resistance and BMI in T2DM children and adolescents. Conclusion: Careful examination of AN along with HOMAIR index calculation and regular monitoring of blood glucose level with BMI should be carried out in order to recognize the incidence of T2DM in children and adolescents.