DOI: 10.36347/sjams.2019.v07i10.004

Pages: 3239-3248

Type 2 diabetes mellitus is a chronic metabolic disorder which has emerged as a health challenge globally due to its insidious on set, late recognition and complications. The present study was aimed at evaluation of oxidative stress markers in Owerri. Cross Sectional Studies was conducted at Federal Medical Center and Imo State specialist Hospital, Owerri. A total of three hundred subjects which include each one hundred and fifty type 2 diabetics and apparently control subjects between the ages forty and sixty nine years were recruited. Ten millimeters of venous blood was aseptically collected from thesubjects. Spectrophotometric, nephlometric, enzyme immunoassay were used for determination of these parameters. The data was analyzed using statistical package for social science 20.0. Test with a probability value of P<0.05 was considered statistically significant. Result from oxidative stress markers showed statistically significantly higher value (P=0.001) in malondialdehyde (2.02 ± 0.32 v 1.76 ± 0.28nmol/l), lower values (P = 0.0001) in glutathione peroxidase, superoxide dismutase, vitamin C and Vitamin E (43.22± 5.74 v 54.77±7.8iu/l, 171. 62 ± 6.91 v 180.55 ± 7.20u/l, 0.84 ± 0.26 v 1.45 ± 0.32mg/dl, 0.80 ±0. 11 v 1.12 ± 0.17mg/dl) when type 2 diabetics was compared with control subjects The female type 2 diabetics had statistically significantly higher value (P = 0.001) in vitamin E when compared with male (0.83±0.89 v 0.77 ± 0.11mg/dl ).