DOI: 10.36347/sjams.2019.v07i10.005

Pages: 3249-3255

Multi drug resistant (MDR) and extensive drug resistant (XDR) Klebsiella pneumoniae infection is very common and causes high morbidity and mortality in community acquired as well as hospital acquired infection. Here, we present a study to detect MDR, XDR and pan drug resistant and characterize extended spectrum β-lactamase, AmpC β-lactamase, metallo β-lactamase and carbapenemase producing K. pneumoniae isolates from different human clinical samples. A total 124 K. pneumoniae isolated from various clinical samples. Antimicrobial susceptibility of K. pneumoniae isolates was performed by Kirby-Bauer disk diffusion. The resistant isolates were tested for ESBL, AmpC, MBL and Carbapenemase production by their respective phenotypic confirmatory test. Distribution of MDR, XDR and PDR detected according to antimicrobial resistance pattern as per guideline. Total 124 K.pneumoniae isolated from various clinical samples, Isolates were maximum resistant to Ceftazidime 81% and least resistant to Imipenem 15%. 45% of K. pneumoniae was MDR, 30% were XDR and no isolate was PDR. ESBL production was seen in 48.3%, AmpC in 6%, MBL in 3.2% and Carbapenemase in 11% of isolates. The study indicates that inadvert uses of antibiotics promote the emergence, persistence, and dissemination of resistant isolates in the community as well as hospital environment. Periodic review of antibiotic policy is necessary for rationalized use of antibiotics.