DOI: 10.36347/sjams.2019.v07i10.015

Pages: 3297-3302

Despite the great improvement in the diagnosis and treatment of systemic lupus erythrometus (SLE) in recent years, lupus nephritis (LN) remained the leading cause of death among SLE patients. So this study was carried out at Department of Nephrology during January 2018 to December 2018 to see the histopathological class of renal involvement in respect to clinical parameters in lupus nephritis and to find any correlation between different clinical parameters and pathological findings. SLE was diagnosed as per American Rheumatism Association criteria. Forty-four patients of SLE having evidence of renal involvement in urine (persistent protienuria with or without urinary cellular casts) were included in the study. Kidney biopsy was done in all cases and histopathological examination (HPE) and Immunofluorescence (IF) examination was done. Staging was done as per world health organization (WHO) classification. The most common age group of LN was 21-30 years. Out of 44 kidney biopsy adequate tissue was found in 38(86.3%) cases. Of 38 HPE done 94.73% had advanced classes of renal involvement. 7.9%, 52.6%, 26.3% and 7.9% were having Class III, Class IV, Class V and class VI-LN respectively. There was significant relationship between age of the patients and musculoskeletal manifestations with histopathological classes. Presence of musculoskeletal manifestation is likely to have proliferative class and more severe illness are likely to have in mature adult. Definite pattern in relation to the severity of the disease when correlated with WHO class was not found in respect of parameters like hypertension, serum creatinine, glomerular filtration rate and 24 hour urinary protein.