DOI: 10.36347/sajp

Pages: 260-267

Dry powder inhaler (DPIs) has attained considerable attention due to their propellant-free formulation and the patient’s inherent coordination with actuation. Dry powder inhaler consist of micronized (<5um) drug alone or mixed with carrier particles. Lactose is the more widely used carrier in dry powder inhalers (DPIs).This study was carried out to investigate the effect of weight fraction of fine lactose as a carriers on aeroionisation behaviour of Mometasone furoate dry powder inhaler.Lactohale 200 and Lactohale 210 two commercial lactose monohydrate were belened in different ratios with fixed amount Mometasone furoate .A low resistance Rotahaler and medium resistance Cyclohaler were used to evaluate the effect of inhaler design on the deposition profiles of Mometasone furoate.Average fill weight per capsule, content uniformity, Uniformity of delivered dose by DUSA, invitro depositon, Moisture content, Assay .Twin stage liquid impinger was used to determine the invitro deposition of Mometasone furoate.Better invitro depositon was observed formulation having lactose ratio (70:30),that is 70% coarse lactose and 30% lactose fine